Synthesis of chiral α-trifluoromethyl amines via asymmetric reactions of trifluoromethylated imines

Abstract

Chiral fluorinated amine compounds are valuable and important synthetic intermediates for the synthesis of biologically active compounds and natural products. Therefore, developing efficient synthetic methods for these compounds holds great significance for both theoretical research and industrial applications. Over the past few decades, chemists have made relentless efforts and developed a series of methods for synthesizing chiral α-trifluoromethyl amines. Herein, we focus on reviewing recent research progress in the synthesis of α-trifluoromethyl amines through asymmetric catalytic reactions of trifluoromethylated imines, mainly divided into two parts: the asymmetric reduction of trifluoromethylated imines and nucleophilic addition to trifluoromethylated imines.