Transition metal-catalyzed selective hydroalkynylation of internal alkynes with terminal alkynes

Abstract

1,3-Enynes are valuable structural motifs found in a variety of natural products and pharmaceutical compounds. They also serve as versatile intermediates in synthetic chemistry due to the presence of multiple reactive sites. Among the strategies for constructing 1,3-enynes, hydroalkynylation stands out for its excellent atom and step economy. However, achieving regio- and stereoselective hydroalkynylation of internal alkynes remains a significant synthetic challenge. This review highlights recent advances in the transition metal-catalyzed hydroalkynylation of internal alkynes and outlines emerging strategies and future prospects of this field.