Palladium-catalysed aminocarbonylation of aryl thianthrenium salts to aryl carboxamides using Mo(CO)₆ as a CO source

Abstract

An efficient palladium-catalysed aminocarbonylation reaction between aryl thianthrenium salts and amines, using Mo(CO)₆ as a solid CO surrogate, has been developed. A wide range of aliphatic and aryl carboxamides, including secondary and tertiary amides, as well as N-aliphatic-linear amides, N-aliphatic-cyclic amides, and N-aryl amides, and some carboxamide derivatives of bioactive molecules such as loratadine, fenofibrate, and cloquintocet-mexyl, have been synthesized under safe and mild conditions and with good to excellent yields and with broad functional group tolerance, including the bromo and iodo groups, offering a new avenue for the production of aryl carboxamides with potential applications.