Electrochemically driven reductive coupling of nitroarenes with alkyl bromides

Abstract

Electrosynthesis, which facilitates redox events under metal-catalyst free conditions, has garnered significant interest. Herein, we explore this promising methodology by introducing an application to the cross-coupling of nitroarenes with alkyl bromides. This approach enables the synthesis of aromatic tertiary amines from readily available and cost-effective starting materials under mild redox conditions. By leveraging the advantages of electrosynthesis, we achieved efficient transformations with good functional group compatibility, thereby contributing to the sustainable modification of valuable bioactive molecules.