SideroGuard: Overview of Siderophore-Enhanced Nanofiber Systems for Biofilm Prevention and Control

Abstract

Over the past several years, there has been an incredible growth in scientific innovation in curing biofilms on chronic wounds. Microbial biofilm is an aggregate of microbial cells surrounded by a polymer matrix that may or may not adhere to surfaces, but present in the tissues or secretions. The free iron involves in biofilm formation, delayed wound healing, and may even be responsible for destruction of connective tissue. To minimize the free iron on wound sites to avoid biofilm formation, the use of siderophores and their derivatives were focused. To address this requirement, researchers have developed various techniques such as non-electrospinning and electrospinning techniques for the formation of nanofibers. Electrospinning has confirmed to be an excellent method for the fabrication of nanofibers which gained the interest of biomedical applications. Electrospinning is a current technique in which electric fields are used to produce fine fibers wherein diameter can be reduced to nanometers which has wide application in the field of medicine. The review aims to discuss the importance of electrospun siderophore-based nanofibers as nanohealers for wound biofilm formation.