SideroGuard: overview of siderophore-enhanced nanofiber systems for biofilm prevention and control

Abstract

In recent years, there has been a considerable increase in scientific innovation regarding the prevention of biofilm formation on chronic wounds. Microbial biofilms are aggregates of microbial cells surrounded by a polymer matrix that may or may not adhere to surfaces and can also be present in the tissues or secretions. Free iron involved in biofilm formation delays wound healing and may even be responsible for the destruction of connective tissue. To reduce the availability of free iron at wound sites and thereby prevent biofilm formation, siderophores and their derivatives have become an area of focus. Researchers have developed various techniques for the formation of nanofibers. Electrospinning is an excellent method that has attracted significant interest for biomedical applications. It involves the use of electric fields to produce fine fibers with diameters that can be reduced to the nanometer scale, and it has wide application potential in the field of medicine. This review aims to discuss the importance of electrospun siderophore-based nanofibers as nanohealers for wound biofilm formation.