Oxidative trifunctionalization of indoles with 2-aminobenzyl alcohols: access to iodo-indoloquinoline scaffolds

Abstract

A facile and environment-friendly synthetic strategy toward iodo-indoloquinolines with high site-selectivity and atomefficiency is reported, featuring an oxidative functionalization of 2-aminobenzyl alcohols with indoles in the presence of molecular iodine under an O2 atmosphere. This methodology enables further indoloquinoline-based transformations and broadens the toolkit for constructing structurally diverse indoloquinoline scaffolds.