Pd(II)-Catalyzed Oxidative Cyclization of Amino Alcohols with 1,3-Cyclohexadiene: A Route to Fused Morpholine Derivatives

Abstract

We have developed an efficient and concise synthetic strategy for the rapid construction of morpholine-fused bicyclic scaffolds under mild aerobic conditions via Pd(II)-catalyzed oxidative cyclization of 1,3-cyclohexadiene with amino alcohol substrates. This protocol enables direct 1,2-aminooxygenation of cyclic dienes, providing access to a range of fused morpholine derivatives with good regioselectivity and yields.