Transition Metal-free Chemoselective Synthesis of C3-Styryl Functionalized Di-/tri-substituted Pyrrole Derivatives and Estimation of their Antimicrobial Properties

Abstract

We have devised a simple and efficient transition-metal-free approach for the synthesis of styryl-linked di- and tri-substituted pyrrole derivatives. The reaction proceeds in a highly chemoselective manner to efficiently deliver the C3-styryl-functionalized mono-ester and di-ester substituted novel pyrrole derivatives under ambient conditions. The key features of this methodology are transition-metal-free conditions, the use of inexpensive building blocks, short reaction times (1 min - 20 min), and a broad substrate scope with good to excellent yields. All the compounds were screened for antimicrobial properties and exhibited selective inhibition against Saccharomyces cerevisiae.