A Lewis base-catalyzed enantioselective O-Boc protection strategy has been developed for the construction of P-stereocenters. Using a chiral DMAP analogue, desymmetrization of P-tethered bisphenols with Boc₂O furnishes P-stereogenic phosphine oxides in decent yields and good to high enantioselectivities.
Y. Wang, X. Chen and J. Xu, Org. Biomol. Chem., 2026, Accepted Manuscript , DOI: 10.1039/D6OB00546B
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