From the journal:

Organic & Biomolecular Chemistry

A supramolecular assembly of a disulfide linked adamantane-curcumin conjugate with amphiphilic cyclodextrin with redox responsive potential

Roberto Zagami,   Chiara Gangemi,   Giuseppe Nocito,   Alberto Aricò,   Maura Monforte,   Paola M Bonaccorsi  and  Antonino Mazzaglia  

Abstract

The synthesis of a novel unsymmetrical disulfide linked adamantane-curcumin conjugate and its supramolecular assembly with amphiphilic cyclodextrin in aqueos dispersion is here reported. Within the nanoassemblies, curcumin derivative was dissolved up to 0.14 mg/mL in ultrapure water and showed high dispersibility also in other biologically relevant media (e.g. NaCl 0.9% wt and PBS pH 7.4), exhibiting redox-responsiveness in the presence of gluthatione as reducing agent.8

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Article information

DOI
https://doi.org/10.1039/D6OB00537C
Article type
Paper
Submitted
02 Apr 2026
Accepted
17 Jun 2026
First published
18 Jun 2026
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2026, Accepted Manuscript

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A supramolecular assembly of a disulfide linked adamantane-curcumin conjugate with amphiphilic cyclodextrin with redox responsive potential

R. Zagami, C. Gangemi, G. Nocito, A. Aricò, M. Monforte, P. M. Bonaccorsi and A. Mazzaglia, Org. Biomol. Chem., 2026, Accepted Manuscript , DOI: 10.1039/D6OB00537C

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