Synthesis of bisindole scaffolds by palladium-catalyzed allylic alkylation of N-aminoindole with ortho-iodoaryl allenes

Abstract

A highly efficient Pd-catalyzed domino allylic alkylation of ortho-iodoaryl allenes with N-aminoindoles has been developed. This protocol enables the synthesis of a variety of diversely substituted N–N scaffold-containing bisindoles under mild reaction conditions. The method features broad substrate scope, good functional group tolerance, and high chemoselectivity, allowing the simultaneous formation of C–C and C–N bonds in a single step.