One-Pot Multicomponent Synthesis of Indole-Linked Fully Substituted Fused-Pyrroles

Abstract

Indole and pyrroles are appreciated owing to their natural and pharmaceutical abundance and impressive biological profile. Herein, we report green, and sustainable non-templated synthesis indole-linked fully substituted fused pyrroles by the multicomponent reactions of arylglyoxals, dimedone, indoles, and anilines. The notable features of the present method include formation of four new bonds (2 C−C, 2 C−N) in one-pot, catalyst-, and metal-free reaction conditions, easy isolation of the products without tedious column chromatographic purification, gram-scale synthesis, and synthesis of pharmaceutically relevant scaffolds.