Photoinduced FeCl3-catalyzed α-C(sp3)–H azolation of primary aliphatic alcohols via LMCT-driven HAT

Abstract

Herein, a visible-light-driven FeCl₃-catalyzed α-C(sp³)–H azolation/coupling reaction of primary aliphatic alcohols has been reported. The reaction achieves the activation of the α-C(sp³)–H bond in primary aliphatic alcohols under mild conditions via an LMCT-promoted HAT process. The protocol is widely applicable to substituted indazoles and other nitrogen-containing scaffolds common in medicinal chemistry, and it is compatible with a wide range of primary aliphatic alcohol substrates.