Photocatalytic α-fluoro-β-phosphonoylation of unsaturated amides

Abstract

We report a redox-neutral photocatalytic strategy for the difunctionalization of α,β-unsaturated amides, enabling α-nucleophilic fluorination and β-phosphonylation via an α-carbonyl cation intermediate. This transformation employs an organic photocatalyst, CBZ6, and proceeds at room temperature, furnishing a series of valuable α-fluoro-β-phosphonoyl amides within 1 hour.