A highly efficient and practical iodine-catalyzed Z-to-E isomerization of enamides under mild conditions is developed. The method exhibits broad substrate scope. Its synthetic utility is demonstrated by gram-scale synthesis and late-stage modification of biorelevant compounds. A plausible mechanism involving iodination, C–C bond rotation, and protodeiodination is proposed.
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Y. Yuan, W. Wang, Y. Wang, D. Feng, S. Peng, C. Ge and P. Huang, Org. Biomol. Chem., 2026, Advance Article , DOI: 10.1039/D6OB00155F
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