One-pot three-component synthesis of hydroxyacetylated imidazo[1,2-a]pyridines via visible-light-mediated halogen atom transfer

Abstract

We devised a protocol for the hydroxyacetylation of the imidazo[1,2-a]pyridine scaffold with diazo esters through a visible light-mediated halogen atom transfer strategy. The diazo substrate was activated by iodine, and oxygen in air acted as a terminal oxidant in the photocatalyst and external oxidant-free reaction. Mild conditions, operational feasibility, fairly wide scope and high yields are the notable features of the methodology.