Palladium-catalyzed reductive Heck cyclization of alkene-tethered carbamoyl chlorides to access CH3- and CH2D-functionalized oxindoles

Abstract

We describe a palladium-catalyzed reductive Heck cyclization of alkene-tethered carbamoyl chlorides for the synthesis of CH₃- and CH₂D-functionalized oxindoles. Notable features of this transformation include its robust scalability and good functional group tolerance. The utility of this approach is further underscored by its successful adaptation to one-pot procedures, offering diverse synthetic pathways to medicinally relevant architectures.