A three-component 1,3-dipolar cycloaddition of pyrazolone-derived azomethine ylides with succinimides for the construction of novel spiro-pyrazolone-pyrrolizines containing succinimides

Abstract

A one-pot, three-component 1,3-dipolar cycloaddition of maleimides with azomethine ylides generated in situ from pyrazolediones and prolines has been developed, and a series of novel pharmaceutically interesting spiro-pyrazolone-pyrrolizines containing succinimides was obtained in moderate to excellent yields with poor to excellent diastereoselectivities.