N-to-C peptide elongation by ammonia-Ugi reaction: synthesis of potent self-assembling elastin-like short peptides

Abstract

The ammonia-Ugi reaction employing ammonium carboxylates of N-protected amino acids (or peptides), ketones, and α-isocyano esters enabled N-to-C peptide elongation, together with in situ construction of α,α-disubstituted amino acid residues. This method offered an effective synthetic method of novel elastin-like short peptides, which exhibited highly potent self-assembling properties.