Green and sustainable nanocatalyzed syntheses of hybrid heterocyclic scaffolds with privileged substructures

Abstract

This review article presents recent advances relating to the use of nanostructured catalysts in the construction of drug-like small hybrid molecules with structural diversity and molecular complexity incorporating medicinally privileged heterocyclic substructures. The nanocatalyzed synthetic methods and reaction mechanisms involving the facilitation of reactions with the interaction of reacting molecules with nanostructured catalysts have also been included. The nanocatalyzed reactions will play a significant role in the design and synthesis of potential pharmaceutical products of structural complexity with desired activity, with fused privileged heterocyclic substructures in their structures. Moreover, the nanocatalyzed synthetic methods are environmentally sustainable and will provide access to a diverse range of natural product mimetic scaffolds through combinatorial chemistry under environmentally sustainable reaction conditions. The present review article will contribute substantially, not only to organic synthesis, catalysis and materials science but also to pharmaceutical and medicinal chemistry, including drug discovery research, in exploring future opportunities in medicinal chemistry.