Radical-promoted cyclization of 3-allyl-2-arylquinazolinones mediated by silver(i) salts to access SCF3/SCN-enriched dihydroisoquinolino[1,2-b]quinazolinones

Abstract

Herein, we describe an efficient approach for the synthesis of SCF₃- and SCN-functionalized polycyclic dihydroisoquinolino[1,2-b]quinazolinones through radical-mediated thio-functionalization of allylic alkenes followed by intramolecular cyclization. The transformation proceeds through sulfur-radical-triggered C–S and C–C bond formation, providing an efficient route to sulfur- and fluorine-enriched polycyclic quinazolinones. Moreover, this strategy offers high atom economy, operational simplicity, and broad substrate compatibility.