Total synthesis of maltepolide F
Bashweshawar S.
Dhulshette 
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and
Subhash
Ghosh
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ab
and
Subhash
Ghosh
*ab
Abstract
Herein, we present the total synthesis of the polyketide macrolide maltepolide F. D-Mannitol serves as the chiral pool material for constructing the tetrahydrofuran unit. Key steps in the synthesis include cyclo-etherification, Brown asymmetric allylation, the Evans aldol reaction, Yamaguchi esterification, and intramolecular Heck cyclization.
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