Direct α-halogenation of carboxylic acids with N-bromosuccinimide (NBS) or trichloroisocyanuric acid (TCCA) in the presence of catalytic amounts of 4-trifluoromethylbenzoic anhydride and H2SO4

Abstract

α-Halogenation of carboxylic acids with N-bromosuccinimide (NBS) or trichloroisocyanuric acid (TCCA) in the presence of catalytic amounts of 4-trifluoromethylbenzoic anhydride and H₂SO₄ in 1,2-dichloroethane was devised. The method does not need prior conversion to acyl chlorides, and the reactions could be applied to a gram-scale synthesis.