Rapid assembly of fluorescence enhanced plasmonic dimers for intracellular single-particle imaging

Abstract

The fluorescence enhanced plasmonic dimers were successfully synthesized by assembled gold nanoparticle and coated by different thickness of silicon shell with yields around 70%, and then adjusted the fluorescences enhancement of Cy5 adsorbed on its surface by controlling the coated SiO 2 shell thickness. In-situ cellular confocal imaging of this dimer fluorescent probe achieve about 9-fold enhancement which matched with the simulation calculations.