Enhancing tumor ROS generation via nanozyme-amplified photodynamic therapy with oxygen-supplying bacterial OMVs

Haibing Dai; Yongqi Wang; Xiang Chen; Jiale Zhu; Han Wang; Daizong Cui; Huibin Wu; Guan Huang; Ran Luo; Jianbo Yu; Weiqun Li; Min Zhao; Lin Mei

doi:10.1039/D5NR04621A

Enhancing tumor ROS generation via nanozyme-amplified photodynamic therapy with oxygen-supplying bacterial OMVs

Haibing Dai,†^ab Yongqi Wang,†^a Xiang Chen,†^d Jiale Zhu,^c Han Wang,^e Daizong Cui,^a Huibin Wu,^d Guan Huang,^b Ran Luo,^c Jianbo Yu,^bd Weiqun Li,*^b Min Zhao*^a and Lin Mei

*^c

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* Corresponding authors

^a College of Life Science, Northeast Forestry University, Harbin 150040, China
E-mail: zhaomin@nefu.cn

^b Longgang Central Hospital of Shenzhen, Shenzhen, China
E-mail: liweiqun@hit.edu.cn

^c State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
E-mail: meilin@bme.pumc.edu.cn

^d Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518116, China

^e Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China

Abstract

In this study, OMV@Hb–Ce6–Mn was constructed by co-loading hemoglobin (Hb) and chlorin e6 (Ce6) onto OMVs, followed by modification with manganese dioxide (MnO₂) nanoparticles. OMV@Hb–Ce6–Mn significantly suppressed tumor growth and elicited potent systemic antitumor immunity, achieving a 50-day survival rate of 83.3%.

Nanoscale

Enhancing tumor ROS generation via nanozyme-amplified photodynamic therapy with oxygen-supplying bacterial OMVs

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Enhancing tumor ROS generation via nanozyme-amplified photodynamic therapy with oxygen-supplying bacterial OMVs

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