From the journal:

Natural Product Reports

A comprehensive review of the structural diversity, biosynthesis and chemical synthesis of Lasiodiplodia spp. natural products

Maria Michela Salvatore, ORCID logo *a   Marco Masi, ORCID logo bc   Marina DellaGreca ORCID logo b  and  Anna Andolfi ORCID logo *bc  

* Corresponding authors

a Department of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy
E-mail: mariamichela.salvatore@unina.it

b Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy
E-mail: andolfi@unina.it

c BAT Center-Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology, University of Naples Federico II, 80055 Portici (NA), Italy

Abstract

Covering: up to the end of 2025

The genus Lasiodiplodia belongs to the Botryosphaeriaceae family. Over the past few decades, it has proven to be a great source of interesting natural products, including depsidones, jasmonates, preussomerins, and β-resorcylic acid derivatives. This review provides an update on the secondary metabolites of 13 species of Lasiodiplodia and their bioactivities, covering the period up to the end of 2025. Further insights into their proposed biosynthetic pathways are discussed, and key examples of the synthetic pathways leading to their production are highlighted.

Graphical abstract: A comprehensive review of the structural diversity, biosynthesis and chemical synthesis of Lasiodiplodia spp. natural products

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Article information

DOI
https://doi.org/10.1039/D5NP00090D
Article type
Review Article
Submitted
18 Dec 2025
First published
21 Apr 2026
This article is Open Access
Creative Commons BY-NC license

Nat. Prod. Rep., 2026, Advance Article

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A comprehensive review of the structural diversity, biosynthesis and chemical synthesis of Lasiodiplodia spp. natural products

M. M. Salvatore, M. Masi, M. DellaGreca and A. Andolfi, Nat. Prod. Rep., 2026, Advance Article , DOI: 10.1039/D5NP00090D

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