Isolation and synthesis of bisabosquals, fungal triprenyl phenol meroterpenoids with a densely functionalised bisabolane core

Abstract

Covering: up to 2026

The Stachybotrys fungi have proven to be rich sources of triprenyl meroterpenoids. In addition to natural products typified by the relatively well known K76, stachybotrin, kampanol and stachyflin are the bisabosquals. The first four bisabosquals were discovered in 2001 and found to have a unique molecular structure displaying an all cis benzopyran-fused benzofuran core. Over the past two decades, this family has been extended, while their novel structure has stimulated efforts focused on their chemical synthesis. Herein, we provide a highlight, covering the isolation, biosynthesis and bioactivities of the bisabosquals and seco-bisabosquals along with studies focused on their total syntheses.