Synthesis, Structure, Catalytic, and Bio Activity of Some Metal Complexes and Coordination Polymer Featuring Imidazo[1,5-a]pyridine and Chromen[4,3-b]pyrrole-4-one

Abstract

A series of M II (M = Ni, Cu, Pd and Pt) complexes and a copper(II) coordination polymer (CP) were synthesized using ligands containing imidazo[1,5-a]pyridine and chromen [4,3-b]pyrrole-4-one moiety. These complexes and CP were explicitly characterized using several spectroscopic techniques and the molecular structures were confirmed by single crystal X-ray diffraction measurement. Computational calculations were also carried out that supports experimental findings. N(II) complexes were employed as catalysts in α-alkylation of acetophenone via hydrogen auto-transfer strategy while palladium counterparts were used to catalyze Heck coupling under mild reaction condition. Presence of m/z peaks due to ligand-bound aryl-Pd(II) and σ-alkyl-Pd(II) intermediates in HRMS indicated the involvement of molecular Pd(0)/Pd(II) catalytic cycle.Copper and Platinum complexes and copper CP were examined for their interaction with biomolecules such as CT-DNA and BSA. The binding interaction of imidazo[1,5-a]pyridine-Pt(II) complex with DNA and BSA was also visualized using molecular docking. This study explored the role of ligand framework on the geometry and reactivity of their bivalent Ni, Cu, Pd and Pt complexes. In both catalytic assessment, Ni(II)/Pd(II) complexes containing imidazo[1,5-a]pyridine ligand was found to be more effective than the corresponding complexes having coumarin-pyrrole moiety.