Silver/molybdenum-promoted skeletal reconstructive cyclization of N-quinolinyl indoles and anthranils

Abstract

A silver/molybdenum-promoted synthesis of structurally diverse functionalized quinolines via skeletal reconstructive cyclization of N-quinolinyl indoles and anthranils was described. The reaction accomplished with moderate to good efficiencies, by tolerating a variety of functional groups. The quinolinyl group bearing on N-position of indole has proved to be essential for enhancing the reactivity. Moreover, the gram-scale synthesis and late-stage modification of the product have been performed to illustrate the potential utility of this strategy.