Fluorescence Quenching of V(III) Ion by 4-Benzylaniline allied Schiff Base Functionalized Organosilane: unveiling Anticancer Potential through In Vitro Analysis and Molecular Docking

Abstract

The present study is concerned with the synthesis of Schiff base functionalized organosilane via click reaction and eventually characterized via 1H and13C NMR, mass spectrum analysis and FT-IR spectroscopy. The synthesized compound demonstrated highly selective and sensitive sensing behavior towards V(III) through UV-visible spectroscopy and fluorescence analysis. The LOD values obtained from absorption and emission spectroscopy are 87.7×10-9 M and 46.4×10-9 M respectively. The binding mode between (5) and V(III) was verifiedby1H NMR, mass spectrum analysis and Infrared spectroscopy (FT). (5) exhibited remarkable antiproliferative property against HeLa cells which has been proved through in vitro and molecular docking analysis. Molecular docking results reveals the effective binding interaction between (5) and tyrosine kinase protein. The findings demonstrate that Schiff base functionalized organosilane is a promising candidate in metal ion sensing and antiproliferative applications, providing a foundation for further exploration of multifunctional sensing and therapeutic functions.