Injectable self-assembled peptide hydrogels with programmable sequences for cell culture

Abstract

This study investigates how subtle variations in amphiphilic peptide sequences and gelation strategies regulate self-assembly and hydrogel formation. Among two peptides with three crosslinking approaches, a CaCO₃ and glucono-δ-lactone (GDL) slow-release method enables stable and cell-compatible hydrogels. The findings provide a rational framework for designing injectable hydrogels for biomedical applications.