Zwitterionic pyridinium N-chloramines: synthesis and antibacterial applications

Abstract

For the first time, zwitterionic pyridinium N-chloramines were synthesized via a multi-step synthesis strategy. Preliminary antibacterial data revealed that spacer variations contributed little to biocidal efficacy enhancement, indicating probable extended spacer conformation of such zwitterionic biocides. However, some linker length variations (such as 15 and 17) resulted in drastically elevated biocidal efficacy. Such data may inspire further exploration of new and potent N-chloramine biocides.