Zwitterionic pyridinium N-chloramine: Synthesis and Antibacterial Application

Abstract

For the first time, zwitterionic pyridinium N-chloramines were synthesized via poly step synthesis strategy. Preliminary antibacterial data revealed that spacer variation contributes little to biocidal efficacy enhancement, indicating probable extended spacer conformation of such zwitterionic biocides. However, some linker length variation (such as 15 and 17) resulted in drastically elevated biocidal efficacy. Such data may inspire further exploration of new and potent N-chloramine biocides.