The Development of a TNTs@MPDA@MnO 2 /CG Composite Hydrogel: Synergistic Multi-Enzymatic Activities and Photothermal Effect for Enhanced Diabetic Wound Repair

Abstract

Diabetic chronic wounds, represent a major clinical challenge due to their high prevalence, impaired healing capacity, and elevated risk of amputation. The core pathology involves persistent bacterial infection and excessive reactive oxygen species (ROS)-induced oxidative stress under hyperglycemic conditions, which disrupt angiogenesis and tissue repair processes. In this study, we developed a multifunctional hydrogel composed of cationic guar gum (CG) embedded with manganese dioxide nanozyme-based nanoparticles (TNTs@MPDA@MnO 2 ), designed for diabetic wound management. The resulting TNTs@MPDA@MnO 2 /CG hydrogel exhibits peroxidase-like activity under acidic conditions and strong near-infrared photothermal response, conferring potent antibacterial properties through synergistic nanozyme and photothermal effects. These properties collectively endow the hydrogel with excellent antibacterial performance, and the favorable biocompatibility confers considerable potential to enhance wound healing.