Triphenylphosphine mediated Ir/Ni Dual Photoredox Catalyzed C(sp2)-C(sp3) coupling of alkyl alcohol and aryl bromide

Abstract

Herein, we present a mild C(sp2)-C(sp3) coupling methodology from alkyl alcohol and aryl bromide under blue light irradiation. The triphenylphosphine mediated alkyl radical generated under photochemical condition was coupled with the aryl bromide in the presence of Ni/dtbpy as catalyst system to provide the C-C coupled product in moderate to good yields. The substrate scope optimization under this condition showed a range of aryl and hetero aryl bromide could be coupled successfully with functionalized benzyl alcohols and other aliphatic alcohols under this condition.