Synthesis of 4-amino pyrrolo and indolo[1,2-a]quinoxalines via copper-catalyzed insertion of o-benzoylhydroxylamines into isocyanides

Abstract

We report a mild and efficient copper-catalyzed method for synthesizing amino-substituted pyrrolo[1,2-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives via the insertion of o-benzoylhydroxylamines into aryl isocyanides. This one-pot cascade transformation enables the simultaneous formation of C–N and C–C bonds, facilitating the efficient construction of heterocycles from diverse o-benzoylhydroxylamines and isocyanide-substituted arene substrates.