HCO2 H-Promoted Hydrolysis of 2-Chloroquinolines to Quinolones

Abstract

Heterocyclic quinolones are ubiquitous in nature and are vital structural motifs bearing with widespread applications in organic synthesis and pharmaceuticals. Herein, a practical and efficient method for the synthesis of quinolones via HCO 2 H-promoted hydrolysis of 2-chloroquinolines is established. This transformation provides direct access to quinolones from 2chloroquinolines under simple conditions. This method enables a concise and scale-up synthesis of the antileishmanial molecule.