From the journal:

Nanoscale Advances

Closing the Loop in Nanotheranostics: From 124I Separation to Intrinsically Radiolabeled Platinum Nanoparticles for Potential PET/CT-Guided Photothermal Therapy

Sanchita Ghosh,   Rajwardhan N Ambade,   Ramu Ram,   Kanhu C Barick,   Apurav Guleria,   Suresh C Sharma,   Minati Nayak,   Amit Kunwar,   Kaustava Bhattacharyya  and  Rubel Chakravarty  

Abstract

Closing the loop in nanotheranostics, we integrate radionuclide production with functional nanomedicine through mesoporous alumina based radiochemical separation of no-carrier-added (NCA) 124I and its direct incorporation into protein functionalized platinum nanoparticles. The intrinsically radiolabeled [124I]Pt@GA shows high labeling efficiency, excellent stability, quantitative PET imaging, and effective photothermal cancer cell ablation.

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Article information

DOI
https://doi.org/10.1039/D6NA00347H
Article type
Communication
Submitted
30 Apr 2026
Accepted
04 Jun 2026
First published
05 Jun 2026
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2026, Accepted Manuscript

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Closing the Loop in Nanotheranostics: From 124I Separation to Intrinsically Radiolabeled Platinum Nanoparticles for Potential PET/CT-Guided Photothermal Therapy

S. Ghosh, R. N. Ambade, R. Ram, K. C. Barick, A. Guleria, S. C. Sharma, M. Nayak, A. Kunwar, K. Bhattacharyya and R. Chakravarty, Nanoscale Adv., 2026, Accepted Manuscript , DOI: 10.1039/D6NA00347H

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