Synthesis of Pluronic F127 Copolymer/Iron Oxide-GelMA Nanocomposite for Doxorubicin Drug Delivery

Abstract

In this research a drug polymeric nanocarriers system consisting of Pluronic F127 copolymer /GelMA iron oxide nanoparticles was prepared to load and release doxorubicin. Various weight ratios of the polymer were used to find the highest drug entrapment rate and an optimal size of composite. The results showed that the maximum rate of drug entrapment in the system was at 57 %. Furthermore, GelMA was synthesized and analyzed by FTIR and FESEM. Various weight ratios of gel were used to obtain an optimal concentration, as well. The swelling rate and degradability of hydrogels were considered. It was found that GelMA with concentration of 10% had more swelling and degradability. Therefore, it was chosen as the optimal concentration. Finally, the drug system was considered by FTIR, FESEM, XRD, TGA and VSM. The results showed that the drug system had slow release and this followed the Korsmeyer-Peppas mechanism.