Resonant Acoustic Mixing-Induced Polymorphic Transformation of Glycine Observed by Solid-State NMR

Abstract

The potential of resonant acoustic mixing for inducing polymorphic transformations is assessed via real-time 13C cross-polarization magic-angle spinning solid-state NMR. Conversion of metastable α-glycine to γ-glycine is sensitive to initial conditions, follows stepwise kinetics which depend on the filling factor of the vial used for RAM, and contrasts with previous results obtained via ball milling.