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Starting from a racemic building block, we introduce a one-pot mechanochemical synthesis of enantioenriched 2-(benzylideneamino)butanamide, a key intermediate to the enantipure drug levetiracetam. Optimisation leads to an ee of up to 94% ee with an overall 80% isolated yield.
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T. Leyssens and G. Wery, RSC Mechanochem., 2026, Accepted Manuscript , DOI: 10.1039/D6MR00053C
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