From the journal:

RSC Mechanochemistry

Mechanoredox radical annulation for the solvent-free synthesis of 2-substituted benzothiophenes

Ji Ho Song,ab   Eunsil Kim,ab   Do Hyun Kang,cde   Ji Young Hyun,ab   Hwan Jung Lim ORCID logo *ab  and  Seong Jun Park ORCID logo *ab  

* Corresponding authors

a Data Convergence Drug Research Center, Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Republic of Korea
E-mail: sjunpark@krict.re.kr
Fax: +82 42 860 7160
Tel: +82 42 860 7175

b Department of Medicinal Chemistry and Pharmacology, University of Science & Technology, Daejeon 34113, Republic of Korea

c A Nano-Lithography & Manufacturing Research Center, Korea Institute of Machinery and Materials (KIMM), Daejeon 34103, Republic of Korea

d Advanced Bioconvergence, University of Science & Technology, Daejeon 34113, Republic of Korea

e Department of Chemistry, Chung-Ang University, Seoul 06974, Republic of Korea

Abstract

A mechanoredox-enabled radical annulation under ball-milling conditions affords 2-substituted benzothiophenes 3 from 2-(methylthio)benzenediazonium salts 1 and alkynes 2. Mechanical energy drives single-electron transfer without photoredox or electrochemical systems, providing a practical and environmentally benign approach to heterocycle synthesis.

Graphical abstract: Mechanoredox radical annulation for the solvent-free synthesis of 2-substituted benzothiophenes

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Article information

DOI
https://doi.org/10.1039/D6MR00013D
Article type
Communication
Submitted
28 Jan 2026
Accepted
04 Apr 2026
First published
08 Apr 2026
This article is Open Access
Creative Commons BY-NC license

RSC Mechanochem., 2026, Advance Article

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Mechanoredox radical annulation for the solvent-free synthesis of 2-substituted benzothiophenes

J. H. Song, E. Kim, D. H. Kang, J. Y. Hyun, H. J. Lim and S. J. Park, RSC Mechanochem., 2026, Advance Article , DOI: 10.1039/D6MR00013D

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