Interfacial mechano-nanoarchitectonics for chemical, materials and biological processes

Abstract

The recent surge of interest in mechanochemistry and mechanobiology indicates a convergence of historical mechanical processes with contemporary nanoprocesses. This review explores the interfacial mechano-nanoarchitectonics in chemical, materials, and biological processes. Active research is being conducted on mechanochemistry, which is more closely related to controlling functional materials through regulating surface structure and property. Advances in probe microscopy have enabled mechanochemistry researchers to analyze various nanoscale phenomena in conjunction with the application of mechanical stimuli. As demonstrated by numerous examples in the field of mechanobiology, the mechanical properties of basic interfaces have the capacity to regulate sophisticated biological properties by conjugating mechanical effects from surfaces. This assertion is applicable to a broad spectrum of targets, ranging from the regulation of cell differentiation to the comprehension of disease mechanisms. In addition, the air-water interface is an optimal location for the mechanical adjustment of nanostructures and molecular structures. The mechanical processes occurring at this interface are characterized by their high efficiency and are driven by delicate forces analogous to those observed in biological systems. The review concludes that interfaces are essential for combining mechanical manipulation as the most traditional method in materials processing with the cutting-edge methodology of nanoarchitectonics.

Article information

Article type
Review Article
Submitted
31 Oct 2025
Accepted
21 May 2026
First published
22 May 2026
This article is Open Access
Creative Commons BY license

RSC Mechanochem., 2026, Accepted Manuscript

Interfacial mechano-nanoarchitectonics for chemical, materials and biological processes

K. Ariga, RSC Mechanochem., 2026, Accepted Manuscript , DOI: 10.1039/D5MR00134J

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