Solvent-Free Continuous Flow Reduction of Aldehydes and Ketones via Mechanochemistry in a Jacketed Screw Reactor

Abstract

We present a simple and efficient solvent-free method for the continuous flow reduction of aldehydes and ketones using sodium borohydride as a reducing agent at room temperature. By employing a jacketed screw reactor, this process achieves nearly complete conversion with residence times ranging from 2 to 10 minutes.The method has been demonstrated on ten representative aldehydes and ketones, highlighting its broad applicability and sustainability. This approach utilizes readily available starting materials, showcasing the potential of Mechanochemistry for green and scalable chemical synthesis.