An N-terminal cysteine-selective click reaction employing N-cyano sulfoximines enables rapid thiazole formation under mild conditions. These three-demensional, hydrophilic scaffolds offer high selectivity, tunable reactivity, and improved drug-like properties. The platform holds promise for bioorthogonal conjugation and ligand design in drug discovery applications.
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E. Kim, J. Y. Hyun, J. H. Song, H. J. Lim and S. J. Park, RSC Med. Chem., 2026, Accepted Manuscript , DOI: 10.1039/D5MD00948K
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