Production of Assorted Nanoparticle Structures using Silver-Cerium Redox Chemistry for Inactivation of Coronavirus

Abstract

Nanoscale cerium oxide is a material of interest for biomedical applications due to the breadth of therapeutic activities demonstrated in research literature. Further, these activities have been shown to be tunable, with control of material surface properties achievable through various wet chemical syntheses. In our previous studies, we have demonstrated unique antiviral performance for nanoscale cerium oxide formulations and related these performances to material properties. In the presented work, we have expanded the space of silver-cerium oxide compositions for use in virus inactivation: examining the effect of synthesis parameters on particle character and of core-shell nanoparticle formulations effects on human coronavirus mitigation. Comparisons among these formulations and a previously reported silver-decorated ceria formulation are made and related to relevant material properties.