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RSC Applied Interfaces

Surface-interactive control of apatite nanoparticles with albumin

Kazuto Sugimoto,ab   Ryota Akutsu,a   Zizhen Liu,ac   Shimon Konosua  and  Motohiro Tagaya ORCID logo *a  

* Corresponding authors

a Department of Materials Science and Bioengineering, Graduate School of Engineering, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka 940-2188, Japan
E-mail: tagaya@mst.nagaokaut.ac.jp

b Japan Society for the Promotion of Science (JSPS) Research Fellowship for Young Scientists (DC), 5-3-1 Koji-machi, Chiyoda-ku, Tokyo 102-0083, Japan

c Japan Society for the Promotion of Science (JSPS) Research Fellowship for Young Scientists (PD), 5-3-1 Koji-machi, Chiyoda-ku, Tokyo 102-0083, Japan

Abstract

The adsorption behavior of albumin (Alb) on the apatite nanoparticles synthesized using different pH-adjusters was investigated in biological fluid. The nanoparticles synthesized using KOH induced the most elastic Alb adsorption through the non-apatitic surface nanolayer, indicating that the Alb adsorption states can be effectively tuned by selecting the appropriate pH-adjuster during nanoparticle synthesis.

Graphical abstract: Surface-interactive control of apatite nanoparticles with albumin

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Article information

DOI
https://doi.org/10.1039/D5LF00247H
Article type
Communication
Submitted
19 Aug 2025
Accepted
08 Jan 2026
First published
22 Jan 2026
This article is Open Access
Creative Commons BY license

RSC Appl. Interfaces, 2026, Advance Article

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Surface-interactive control of apatite nanoparticles with albumin

K. Sugimoto, R. Akutsu, Z. Liu, S. Konosu and M. Tagaya, RSC Appl. Interfaces, 2026, Advance Article , DOI: 10.1039/D5LF00247H

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