Emerging non-viral gene delivery platforms provide alternatives to viral methods. However, they remain limited in scalability and efficiency for clinical translation. We present a fractal-shaped droplet microfluidic system that achieves approximately 98% efficiency and 80% viability at throughputs exceeding 107 cells per min, enabling efficient, large-scale, and clinically relevant cell engineering.
M. Sung, D. Jing, B. Joo, S. Im, Y. Kim, Y. Sui and A. J. Chung, Lab Chip, 2026, Advance Article , DOI: 10.1039/D5LC00865D
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