Resting-State Brain Connectivity Following Extra Virgin Olive Oil Intake in Healthy Adults: A Randomised Crossover Pilot Neuroimaging Substudy

Abstract

This pilot randomised crossover neuroimaging substudy (n = 9) identified increased resting-state occipital functional connectivity following daily consumption of (poly)phenol-rich extra virgin olive oil compared with regular olive oil. Urinary hydroxytyrosol-glucuronide excretion increased significantly, and a significant interaction between intervention and metabolite levels was observed on occipital connectivity. These preliminary findings require replication in larger, adequately powered studies.