Carbonylation with 3d Metal Hydrides: Expanding the Potential for Industrial Application

Abstract

Metal-hydride-mediated carbonylation toward value-added products has found broad applications in synthetic chemistry, materials science, pharmaceuticals, and industrial catalysis, exemplified by hydroformylation and Reppe-type carbonylation. However, most of these applications rely on highly active but precious metal catalysts. Therefore, the development of novel, practically useful, and inexpensive catalytic systems based on earth-abundant metals is highly desirable. On the other hand, olefin isomerization-carbonylation tandem processes can assist in converting mixed olefins into single products, which is of relevance to chemical industry applications. In this review, we summarize and discuss recent advances in abundant metalhydride-mediated carbonylation and its isomerization-carbonylation tandem process (chain-walking carbonylation), with the aim of providing insights to researchers in both organic chemistry and industrial catalysis for future reaction design.