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Dalton Transactions

Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

Abdul Salam,   Goraksha T. Sapkal,   Bodhidipra Mukherjee,   Sakshi Chouhan,   Richa Garg,   Shilpa Chandra  and  Chayan Kanti Nandi  

Abstract

The endoplasmic reticulum (ER) undergoes dynamic morphological changes during cellular stress and disease, yet specific staining and nanoscale observation remain challenging. We report a highly bright, biocompatible, and nontoxic fluorescent Zn-complex for super-resolution imaging of the ER. Super-resolution radial fluctuation microscopy (SRRF) resolves the smallest tubular diameter of ER, 110 nm, and quantifies stress-induced morphological remodeling.

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Article information

DOI
https://doi.org/10.1039/D6DT00345A
Article type
Paper
Submitted
09 Feb 2026
Accepted
23 Mar 2026
First published
24 Mar 2026

Dalton Trans., 2026, Accepted Manuscript

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Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

A. Salam, G. T. Sapkal, B. Mukherjee, S. Chouhan, R. Garg, S. Chandra and C. K. Nandi, Dalton Trans., 2026, Accepted Manuscript , DOI: 10.1039/D6DT00345A

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